教員紹介

Professor

Nakao Miki

Research Interests

“Elucidation of structure, function and their diversity of the complement system in fish”
“Comparative Immunology of innate immune factors in aquatic vertebrates and invertebrates”
“Elucidation of crosstalk between innate and adaptive immune systems in fish”

Laboratory

Activity Database

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Outline Activities

My major research interest is structural and functional diversity of the complement components in bony fish. In contrast to mammalian complement system, bony fish have multiple copies of the genes encoding several complement components such as C3, C4, C5 and factor B/C2. Currently I am analyzing biological and evolutionary impact of the complement diversity on the innate immunity of the bony fish. Data obtained will be utilized for establishment of prevention of infectious diseases, which damage many kinds of cultured fish stock, and also for genotype-based selection of fish lineage with higher degree of host defense. Other research subject of my interest is phylogeny of the innate and adaptive immune system. Molecular cloning of innate immune components such as cytokines, complement components, and lectins will give some insights into genetic (genomic) mechanism that generated a number of immune-related genes in the lower vertebrates and invertebrates. Application of the finding obtained by the studies will be of importance to develop better means of disease prevention in fish and invertebrate aquaculture.

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Educational Activities

Undergraduate School

Laboratory Exercise of Basic Chemistry
Marine Biochemistry I
Marine Biochemistry II
Field Trip for Study
Physiology II

Graduate School

Molecular Biosciences I
Comparative immunology
Molecular Bioscience I（IGP）
Master's Thesis Research II
Seminar in a Specified Field II
Master's Thesis