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教員紹介
IKEGAMI Keisuke
Research Interests
“Molecular mechanisms of photoperiodic time-measurement in seasonal reproduction in vertebrates”
“Regulatory mechanisms of pineal gland on circadian physiological functions”
“Regulatory mechanisms of pineal humoral factors on mood in mice”
“Understanding of molecular mechanisms on circadian intraocular pressure rhythm for glaucoma chronotherapy”
“Mechanisms of lifestyle on glaucoma development”
“Understanding of Glaucoma by data science ”
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Outline Activities
Many organisms living on the Earth have a circadian clock with about 24-hour period, allowing important physiological functions to adapt to ambient light-dark cycle. A master clock in the brain called the suprachiasmatic nucleus (SCN) governs peripheral rhythms via hormonal and neural pathways. Furthermore, this clock is also important for seasonal responses by photoperiodic time measurement. Understanding these mechanisms will not only contribute animal reproduction and health, but also lead to breakthroughs in solving various issues facing modern society.
Currently, we are using mice, cells, and BIG data to understand glaucoma, which has the highest rate of blindness by using medical, behavioral, molecular biological, histological, physiological, functional, and data science techniques. We aim to elucidate the molecular mechanism underlying diurnal rhythm of intraocular pressure (inner eye pressure), and the relationship with lifestyle.
In addition, melatonin in the pineal gland, known as a sleep hormone, is known to be important in the circadian regulation and seasonal responses. However, its effects on other physiological functions remains uncovered. Furthermore, although pineal humoral factors other than melatonin are also synthesized, their functions also remain unclear. Therefore, we are trying to elucidate the physiological regulation of the pineal gland on the circadian clock, behavior, mood, and perceptual functions.
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We are recruiting graduate students. If you are interested in biological rhythms, eye science, and endocrine systems, please contact us.
Educational Activities
Undergraduate School
Animal Physiology I
Laboratory Exercise in Feed Science
Laboratory Exercise of Animal Husbandry
Seminar in Graduation Thesis
Science English
Animal Care and Regulatory Biology II
Graduate School
Advanced Lecture on Muscle and Meat Sciences